In late 1967, a young orphaned boy goes to live with his loving grandma in the rural Alabama town of Demopolis. As the boy and his grandmother encounter some deceptively glamorous but thoroughly diabolical witches, she wisely whisks him away to a seaside resort. Regrettably, they arrive at precisely the same time that the world's Grand High Witch has gathered.

A young boy named Luke and his grandmother go on vacation only to discover their hotel is hosting an international witch convention, where the Grand High Witch is unveiling her master plan to turn all children into mice. Will Luke fall victim to the witches' plot before he can stop them?