After accepting an invitation from a mysterious trainer, Ash, Misty and Brock meet Mewtwo, an artificially created Pokémon who wants to do battle.

The Kingdom of the People of the Earth once ruled over the land, but now all that remains is the Sword of the Earth. in the city of Eindoak. Satoshi, Iris, and Dent arrive in Eindoak during a harvest festival's Pokémon Tournament and meet the legendary Pokémon Victini who wishes to share its powers of victory to someone. Elsewhere in the city, a descendant of the People of the Earth named Dred Grangil has arrived who seeks to revive the kingdom's power with the Sword of the Earth, bringing them back into power over the land, and Satoshi and his friends must stop him before he destroys the land along with Victini.

Determined to prove its superiority, a bio-engineered Pokémon called Mewtwo lures Ash, Pikachu and others into a Pokemon match like none before.

After he inherits some money, Harold Bissonette ("pronounced bis-on-ay") decides to give up the grocery business, move to California and run an orange grove. Despite his family's objections and the news that the land he bought is worthless, Bissonette packs up and drives out to California with his nagging wife Amelia and children.