When Susan Murphy is unwittingly clobbered by a meteor full of outer space gunk on her wedding day, she mysteriously grows to 49-feet-11-inches. The military jumps into action and captures Susan, secreting her away to a covert government compound. She is renamed Ginormica and placed in confinement with a ragtag group of Monsters...

Susan Murphy (a.k.a. Ginormica) and the Monsters are now working with the US government as special ops. So when an alien presence is detected in Susan's hometown of Modesto, California -- right before Halloween -- the team is dispatched to investigate. Everything appears normal, right down to the jack-o-lanterns peering out from every doorstep and windowsill. But when Halloween arrives, those innocent-looking carved pumpkins reveal themselves for what they really are mutant aliens. The altered pumpkins then start to implement their fiendish plan to take over Earth. The Monsters are there to combat the mutant gourds and try to smash their wicked scheme!

Dr. Cockroach comes up with a brilliant plan to break themselves out of Area 52 – but to implement the plan, he has to trick B.O.B. into thinking it’s his birthday.