The film was made up of photographs of interior sets combined with exteriors to establish the beginning and the end of the film. The first scene is of a New York street where a sightseeing bus is about to start off on a trip. Then the interiors, using actors, begin. A guide with a megaphone escorts a country couple through a vaudeville show-restaurant and an opium den. The country bumpkins are enthusiastic about the tour. The last scene shows the bus loaded with tourists returning to its starting point. Broadway at 38th street, New York City.

Pandora's Box unmasks the global pandemic of menstrual inequity and period poverty. From Maasai villages, to Mumbai and on to London, we meet young women who are forced to stay at home from school, or even drop out, merely because they don't have access to menstrual supplies. We meet formerly incarcerated women in the U.S. prison system who talk about their struggles to menstruate safely while deprived of basic human hygiene. One of them asks: "Isn't the ability to menstruate with dignity a basic human right?"