Hope's Peak Academy is a special school, recognized by the government, that was established in order to gather and nurture top-class students who excel in various fields. This school has two courses: The main course, and the preparatory course. Anyone with the money can enter the preparatory course, even if they don't have any special skills. The 77th class of the main course is filled with students who not only have unique abilities, but unique personalities as well. However, the students learned that "Talent isn't the most important thing in life; it's to involve yourself with people and make yourself a better person while making memories." However, little did they know that a mysterious project and discrimination of the courses were happening right under their noses. Hajime Hinata, a boy from the preparatory class who craves for an ability. The fateful meeting he has drives the future of the school into an unimaginable direction.

Fourteen-year-old Iruma Suzuki has just been abandoned and sold to a demon by his irresponsible parents! Surprisingly, the next thing he knows he's living with the demon who has adopted him as his new grandson and has been transferred into a school in the Netherworld where his new demon grandfather works as the principal. Thus begins the cowardly Iruma-kun's extraordinary school life among the otherworldly as he faces his true self, takes on challenges, and rises to become someone great.

Being just a normal student without a special talent, Makoto Naegi wins a lottery to attend the prestigious Hope's Peak Academy where only the top prodigies attend. However, instead of this being the beginning of a wonderful high school life, it's a ticket to despair, because the only way to graduate from Hope's Peak Academy is to kill one of your fellow students or be one of their victims.