Tony Lip, a bouncer in 1962, is hired to drive pianist Don Shirley on a tour through the Deep South in the days when African Americans, forced to find alternate accommodations and services due to segregation laws below the Mason-Dixon Line, relied on a guide called The Negro Motorist Green Book.

After crossing the border illegally for work, Miguel, a hard-working father and devoted husband, finds himself wrongfully accused of murdering a former sheriff’s wife. After learning of his imprisonment, Miguel’s pregnant wife tries to come to his aid and lands in the hands of corrupt coyotes who hold her for ransom. Dissatisfied with the police department’s investigation, the former sheriff tries to uncover the truth about his wife’s death and discovers disturbing evidence that will destroy one family’s future, or tear another’s apart.

After their father (public figure and arms dealer to the cartel) passes away, two brothers on the opposite sides of the law are forced to reunite. One struggles to keep his fathers secrets as he runs on a political campaign, the other is forced into his old business.