Inspector Clouseau disappears, and the Surete wants the world's second best detective to look for him. However, Clouseau's enemy, Dreyfus, rigs the Surete's computer to select, instead, the world's WORST detective, NYPD Sgt. Clifton Sleigh. Sleigh obtusely bungles his way past assassins and corrupt officials as though he were Clouseau's American cousin.

After dying during a gun fight, a bunch of gangsters have their spirits trapped inside panties. Ashley chants a magic spell for luck....but that very moment, a gun fight breaks out across town. The spirits of newly-dead jewel thieves are suddenly sucked back to Earth - right into the girls' panties! The girls are infested with something far more itchy than fleas. The gangster-spirits hop from panty to panty.... and burrow through the FireWire, infecting all the models. In the meantime, Guido - the only gangster that escaped, sets out to interrogate the ill-behaved Spirits in each model's panties to learn the whereabouts of the missing Queen Shockra Jewel. Will the girls be able to release the gangsters from their panties and live normal lives? Can they help find the priceless jewel? Time is running out as they try to defeat the Curse Of The Pink Panties.

After neutralizing the original curse, Guido, the jewel smuggler who was the only gangster to survive the shoot out in the warehouse, has learned that the spirits of those who were deceased in the gunfight have returned to once again torment the ladies. Guido must know gather himself and figure out who is responsible for the black magic that has brought back the curse.