When a casino-owning dog named Charlie is murdered by his rival Carface, he finds himself in Heaven basically by default since all dogs go to heaven. However, since he wants to get back at his killer, he cons his way back to the living with the warning that doing that damns him to Hell. Once back, he teams with his old partner, Itchy, to prep his retaliation. He also stumbles onto an orphan girl who can talk to the animals, thus allowing him to get the inside info on the races to ensure his wins to finance his plans. However, all the while, he is still haunted by nightmares of what's waiting for him on the other side unless he can prove that he is worthy of Heaven again.

Charlie and Itchy return to Earth to find Gabriel's Horn, but along the way meet up with a young boy named David, who ran away from home.

Join Charlie (voiced by Steven Weber) and his canine friends Itchy (Dom DeLuise), Anabelle (Bebe Neuwirth) and Sasha (Sheena Easton) on another round of hair-raising adventures in this collection of episodes from the popular animated series, based on the 1989 Don Bluth film. A foursome of episodes focusing on the theme of friendship includes "Field Trip," "Cyrano de Barkinac," "Mutts Ado About Nothing" and "Heaventh Inning Stretch."