Professor Charles Xavier and his team of genetically gifted superheroes face a rising tide of anti-mutant sentiment led by Col. William Stryker. Storm, Wolverine and Jean Grey must join their usual nemeses—Magneto and Mystique—to unhinge Stryker's scheme to exterminate all mutants.

It's a major double-cross when former police officer Brian O'Conner teams up with his ex-con buddy Roman Pearce to transport a shipment of "dirty" money for shady Miami-based import-export dealer Carter Verone. But the guys are actually working with undercover agent Monica Fuentes to bring Verone down.