Twenty-two of the most iconic, boldest, and fiercest Challenge All Stars from the original The Real World and Road Rules return for a second chance at the ultimate competition as they vie for their shot at the $500,000 grand prize. Follow the competitors as they face unprecedented, over-the-top challenges set in the Andes Mountains of Argentina.

Each Challenge pits numerous cast members from past seasons of reality shows against each other, dividing them into two separate teams according to different criteria, such as gender, which show they first appeared on, whether or not they're veterans or rookies on the show, etc. The two teams compete in numerous missions in order to win prizes and advance in the overall game.