Seven years after the events of the first film, Samantha Darko finds herself stranded in a small desert town after her car breaks down where she is plagued by bizarre visions telling of the universe's end. As a result, she must face her own demons, and in doing so, save the world and herself.

Suwisal has turned 40. He's a forgetful businessman, a philanderer, indifferent to life around him, including his young and lovely fiancée. A visit to the house of his childhood triggers memories that continue to cascade when he is called for jury duty to hear the case against Piyum, a servant he seduced and abandoned 20 years before. Now a prostitute, she is on trial for murder.