A non-fiction investigative series of murder cases told through the personal experience of retired detective, Lieutenant Joe Kenda. Through re-enactments, discussions with investigation teams, and interviews with victims' families and other involved persons, the show highlights Kenda's successes with his 400 homicide case history and 92 percent solution rate.

In American Detective, Kenda trades in his own case files to bring viewers astounding investigations from across the country, with each episode featuring a different homicide detective whose tireless efforts helped put a killer behind bars and bring justice for the victim.