Andy Hardy becomes entangled with three different girls all at the same time.

Flighty Emily "Jacks" Jackson works for the British edition of Vogue magazine. Rather than pursue a relationship, Jacks regularly hooks up with her devoted ex-boyfriend, James Wildstone, and lives with Peter Simon, a gay screenwriter. When Jacks meets Argentinian photographer's assistant Paolo Sarmiento, she assumes he is gay and tries to bring him and Peter together, unaware that Paolo is straight and in love with her.

Khaila Richards, a crack-addicted single mother, accidentally leaves her baby in a dumpster while high and returns the next day in a panic to find he is missing. In reality, the baby has been adopted by a warm-hearted social worker, Margaret Lewin, and her husband, Charles. Years later, Khaila has gone through rehab and holds a steady job. After learning that her child is still alive, she challenges Margaret for the custody.

All his life, African-American Renato has been raised in an Italian-American family. Completely unaware that he is Black, his life is upended when his birth parents materialize, causing Renato to examine what he true heritage is.

Chloé, a fragile young woman, falls in love with her psychoanalyst, Paul. A few months later she moves in with him, but soon discovers that her lover is concealing a part of his identity.

A young writer begins an affair with an older woman from France whose open marriage to a diplomat dictates that they can meet only between the hours of 5 p.m. to 7 p.m.

The Malacicis, a hard-working Italian family recently immigrated from Florence, open a fancy restaurant in the Bronx, N.Y., drawing the ire of another clan. Mike and Sadie Capomezzo, equally hard-working Sicilian caterers from the area, find they cannot stand Piero and Maria Malacici. But things get complicated when the Malacicis' daughter, Gina, and the Capomezzos' son, Rosario, fall in love.

In a Canadian metropolis, failed actor David shares a place with the bookish Candy, whom he dated before coming out as gay. While David, who now waits tables, pursues an aimless romance with a younger coworker, Candy dabbles in both same-sex and heterosexual affairs. As David and Candy's odd assortment of friends — including a telepathic sex worker and an ill-tempered yuppie — pass in and out of their beds, a serial murder stalks the city's women.