"Single is the best" is the slogan of the free-spirited single lady Waenpetch, who's an editor for the Lovely Family magazine, and the gentle flower shop owner Laising. They both don't believe in marriage. One day, they meet at a wedding when they accidentally catch the bouquet at the same time. They become friends since they share the same views about love and marriage, but what's going to happen when they start to have feelings for each other?

Haru and Kanako have been married for four years. They don't have any children, but they both enjoy their job and are happy together. However their lives are suddenly disrupted when Kanako faints from subarachnoid hemorrhage. After the operation, it becomes evident that she has lost some of her memory...her memory of the five years with her husband. She decides to return home to her parents. Her younger brother takes care of her. Meanwhile, Haru's colleague notices that there is something troubling him. Life without his wife makes Haru realize how much his wife means to him and vows to propose to her once again...

Bai Shao, Bai Ji, and Bai Su, daughters of a Chinese medicine practitioner named Bai Shou Cheng, are all troubled with relationship problems. Bai Shao and Bai Su don't want to carry on their father's occupation, so they decide to wait until their father remarries, goes to America to start his new life, and then they'll work on their lives. Bai Shao started a fake relationship with Lu Liu An, who is younger than her. Bai Ji's husband is having an affair and decides to divorce her. Bai Su somehow falls in love with a much older man whose profession is also related to the medical field. Within each relationship, there are new problems arising. Seeing his daughters trapped in troubled situations, Bai Shou Cheng decides to stay and delays his trip to America in order to help his daughters achieve happiness.

The rising death rate in terminally ill patients raises a doubt in Police Major Wasan's heart he cannot shake. Recently, just before he could make it back to her, his mother has passed away. Given the circumstances, she may be one in a series of suspicious deaths.

Dr. Kantaphat, the doctor who'd taken care of Wasan's mother in her final days, becomes important to his grieving heart. The deeper his feelings grow, however, the more the mystery seems to link back to his lover, bit by bit.