Simon Anthony Abou-Fadel's French/Lebanese father, Edward, and French/Egyptian mother, Françoise, settled in North Hollywood in 1969 As a kid there Simon poignantly remembers the nights he and his older brother would wait up to watch the family's garage door for the first flickering reflections from the screen of the nearby drive-in movie. From those nights, he marks his fascination with movie screens, with the actors who inhabit them, and with the industry that was then only a few streets away. Simon plays William Douchet in Chuck Russell's Witchboard and Jack Dalton in Jamie Foxx and John Eisendrath's Alert: Missing Persons Unit. He has landed roles on notable network shows such as Veronica Mars, 24, and Law and Order Los Angeles. Notable roles also include Adrian Holmes' lawyer in the English version of 19-2, Ed Greenstein in the reboot of iconic Canadian television show Street Legal, and working opposite Mia Kirshner in The Detectives, David James Elliot in Real Detectives and with Trish Helfner in Ascension. Among others, he can be seen in Quantico, The Art of More, The Bold Type, The Republic of Sarah and Transplant with John Hannah and Hamza Haq. Simon Anthony Abou-Fadel is also the narrator for the new IMAX film entitled Train Time.

Simon was a company member at The Actors Gang Theatre in Los Angeles, California, with Artistic Director and film actor Tim Robbins. During his seven years with the Gang, he toured nationally in Embedded, an original play by Robbins, and appeared in a critically acclaimed production of Tartuffe directed by Jon Kellam in which he was reviewed by the Hollywood Reporter that touted his "strong support". Backstage also affectionately praised him and scene partner Lindsley Allen for their scenes, and the Los Angeles Times claimed Allen and he "attained absolute lunacy". While at The Gang, Simon accepted an invitation from the Walt Disney Concert Hall to act in a two-person play with the L.A. Philharmonic Orchestra providing live background music.