Louis Robert Wolheim (Nova York, 28 de març de 1880 – Los Angeles, Califòrnia, 18 de febrer de 1931) va ser un actor nord-americà, tant d'escenari com de pantalla, l'aspecte físic del qual el va relegar a papers majoritàriament de pinxo o malvat a les pel·lícules, però el talent del qual li va permetre florir a l'escenari.

It was Lionel Barrymore who gave Louis Wolheim his start as an actor. Wolheim had had his face more or less smashed in and his nose nicely fractured while playing on a scrub Cornell football team. Later as a Cornell Instructor he found life none too easy. He had worked off and on as an extra in the Wharton studio but never received much attention. Barrymore had only to look at him once to realize that Wolheim's face was his fortune. Through Barrymore, Wolheim gained an entree into New York theatrical life. On the legitimate stage he made a great success in "Welcome Wing" and "The Hairy Ape", climaxing these plays by his triumph in "What Price Glory". Louis Wolheim died in Los Angeles, California on 18 February 1931, the result of stomach cancer.