General Hospital: Night Shift is an American prime time serial that first aired on Soapnet for a 13-episode run from July 12, 2007 to October 4, 2007. A spin-off of the ABC Daytime soap opera General Hospital, the show is SOAPnet's first original scripted drama series and follows the nighttime adventures of familiar and new characters around the hospital. As of March 2008, the first season of the series was "SOAPnet's most watched series ever," with ABC Daytime and SOAPnet President Brian Frons noting that Night Shift drew more than 1 million new viewers to the channel during its first season. With its reruns gaining higher ratings than those of General Hospital on SOAPnet, a second season was expected, though Frons noted that the same crew producing two shows had taken its toll.

It was announced in May 2008 that Lisa de Cazotte would serve as Executive producer for season two, joined by Head writer Sri Rao. The 14 new episodes of Night Shift began taping in high-definition in June 2008, with the series airing Tuesdays at 11 p.m. and premiering on July 22, 2008. SOAPnet said the second season "will feature new and returning characters as well as the return of 'legacy' characters from GH. In addition, the continuity between story lines on Night Shift and GH will match." The second season finished its run on October 21, 2008.

Skin is a television serial drama which aired at 9:00 p.m. Monday on Fox in 2003. It followed the tale of two teenagers who came from feuding families on opposite sides of the moral and legal spectrum. Adam is the son of the Los Angeles District Attorney, and Jewel is the daughter of a pornographer. The show is a modern-day take on the Romeo and Juliet story. Even after an incredible amount of advertising, the show was cancelled after only three episodes due to poor ratings and less than favorable reviews. It was reprieved in 2005, when SOAPnet acquired broadcasting rights to all eight episodes and aired the last five episodes for the first time.

1 Day With is an American reality series which premiered on Soapnet in September 2004. Soap actor Wally Kurth follows a daytime soap actor around throughout their day. At various times Kurth has taken singing lessons, done martial arts, helped cook dinner, and volunteered for a charitable cause.

The actors who have appeared on 1 Day With include:

⁕From One Life to Live: Kathy Brier, Hillary B. Smith, Kassie DePaiva

⁕From General Hospital: Tamara Braun, Rick Hearst, Ingo Rademacher, Tyler Christopher, Alicia Leigh Willis, Anthony Geary, Scott Clifton

⁕From Days of our Lives: Bryan Dattilo, Alison Sweeney, Peter Reckell, Matthew Ashford, Arianne Zucker

⁕From The Bold and the Beautiful: Sean Kanan

⁕From All My Children: Eva LaRue, Cameron Mathison

⁕From The Young and the Restless: Kristoff St. John

Greg Behrendt's Wake-Up Call was an American reality television series that premiered on SoapNet on January 8, 2009. The series was hosted by stand-up comedian and author Greg Behrendt.

The series, like Behrendt's previous effort, specialized in dealing with couples and their relationship problems. The major difference between Wake-Up Call and The Greg Behrendt Show was that the relationships were dealt with in person rather than in a television studio.

Originally, Wake-Up Call was supposed to air on ABC in the 2006-2007 season, as the six-episode series was scheduled to be a midseason replacement. However, ABC never aired the episodes and the series sat unaired for two years until corporate sibling SoapNet began airing the series. The final episode aired on February 12.

Southern Belles: Louisville was an American reality television series on the Soapnet cable network that aired for one season from May 21 to July 23, 2009. The show focused on the lives of five women in Louisville, Kentucky.

Soap Talk is a television talk show on SOAPnet hosted by Lisa Rinna and Ty Treadway. It debuted in 2002 and ended in 2006. The reason for the show's cancellation was due to SOAPnet expanding their programming away from a soap opera-related focus.