Dorothy Castlemore arrives at Dumas College wanting to join the sorority Mu Sigma Theta, the place where her beloved grandmother felt at home and a place where she hopes to be accepted as well.

The Great White Sharks are a sisterhood, there for each other through first loves, new jobs, bad breakups, and everything in between. But they are also elite athletes, idolized by thousands and members of the best all-star cheerleading team in the world. Cheer Squad follows the two-time World Cheerleading Champions on the long road to defending their title as they try to balance life off the mat with the all-consuming battle to stay on top.