Best Friends follows the life of a group of friends at their high school ‘Spangalis College’. Inside and outside of school exciting and challenging experiences take place. Growing up is never easy; every character has its own, unique story of love, friendship, loneliness, sorrow, discovery. There is drama and joy in school, family, teachers, parents, divorce, bullying, and always dreams for the future.

Following a major catastrophe, a new society, Arcadia, is born. Resources have become scarce and a point system, known as the Citizen Score, is introduced. It determines what you can and may do and what a citizen is entitled to.

The weekend Anne (24) moves into her own place she unexpectedly runs into her ex-girlfriend Lily, and a lot has happened since they broke up four years ago. Over the weekend, Anne reflects on the relationships she has had throughout her student years in Amsterdam.

Carmen, the daughter of a notorious Amsterdam drug lord, reluctantly takes charge of the family's smuggling business in order to clear her husband's debts.

Mourning the death of her husband Simon, supposedly killed in a plane crash, Liv is shocked to discover that Simon lied to her and was not a passenger on the tragic flight. Seeking the truth surrounding her husband’s mysterious disappearance, Liv uncovers secrets that threaten to destroy her entire family…

Fay (14) and Boris (10) discover that their parents secretly replaced themselves by robots. Claudia and Joost each have demanding jobs and even though they try very hard, they are not able to combine their jobs with spending quality time with their children. Boris, Fay, Claudia and Joost slowly realize they need each other as a family and when the robots become uncontrollable, they can only clear up the mess by working together.

After wrecking his car in a deserted road in the middle of the forest and being found with the blood and mobile phone of his niece, successful criminal lawyer Daniel Elias can no longer remember who he is but must find a way to prove his innocence, even though he does not know whether he is guilty or not.

The story of a group of teenagers in high school in Utrecht, The Netherlands, in their search for friendship, love, their own identity, and overcoming fears.