Henry's parents are lost in Africa, so he must live with his greedy and heartless Uncle Augustus. In the crevices of the house live the "Littles" kind, elf-like creatures. August enslaves Henry and wants to tear down his house to build a shopping center. Grandpa Little cares for Tom and Lucy, the Littles' children. Tom befriends a vicious cat by removing a splinter from his paw. After a series of adventures, the Littles and Henry get evidence of Augustus' plot to steal Henry's home. Augustus is arrested, the house is saved, and all ends well.

Les parents d'Henry sont perdus en Afrique, il doit donc vivre avec son oncle Auguste avide et sans coeur. Dans les crevasses de la maison vivent des créatures semblables à des elfes. Mais August projette de démolir sa maison pour construire un centre commercial.