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Keiko, daughter of a famous sushi chef, leaves home to escape his overbearing training in both sushi-making and martial arts. Finding work at a rural inn, she is bullied by the staff and ridiculed by the guests, including the president of Komatsu Pharmaceuticals, who has come to the inn for a vacation with his associates. Little do they know, however, that disgruntled Komatsu researcher Yamada has followed them there with designs on revenge, using a serum he developed that can awaken the murderous instincts of fish on rice, creating…killer sushi! Bloodthirsty tuna and squid soon descend upon the humans, killing many and turning the remainder into zombie-like creatures.