In the Mexican town of Santa Clara, Salma, a 16 year-old orphan who never got to meet her biological parents, has spent most of her life searching for clues of their identities and whereabouts, that is until she discovers a special book that is filled with stories of the town's past and the history of it's people.

When young Buddy falls into Santa's gift sack on Christmas Eve, he's transported back to the North Pole and raised as a toy-making elf by Santa's helpers. But as he grows into adulthood, he can't shake the nagging feeling that he doesn't belong. Buddy vows to visit Manhattan and find his real dad, a workaholic publisher.

Joe Dirt is a janitor with a mullet hairdo, acid-washed jeans and a dream to find the parents that he lost at the Grand Canyon when he was a belligerent, trailer park-raised eight-year-old. Now, blasting Van Halen in his jacked-up economy car, the irrepressibly optimistic Joe hits the road alone in search of his folks.

Adopted as a child, new father Mel Colpin decides he cannot name his son until he knows his birth parents, and determines to make a cross-country quest to find them. Accompanied by his wife, Nancy, and an inept yet gorgeous adoption agent, Tina, he departs on an epic road trip that quickly devolves into a farce of mistaken identities, wrong turns, and overzealous and love-struck ATF agents.

An uptight professional meets his lower-class biological parents for the first time.

When Lenny and his wife, Amanda, adopt a baby, Lenny realizes that his son is a genius and becomes obsessed with finding the boy's biological mother in hopes that she will be brilliant too. But when he learns that Max's mother is Linda Ash, a kindhearted prostitute and porn star, Lenny is determined to reform her immoral lifestyle. A Greek chorus chimes in to relate the plot to Greek mythology in this quirky comedy.

Khaila Richards, a crack-addicted single mother, accidentally leaves her baby in a dumpster while high and returns the next day in a panic to find he is missing. In reality, the baby has been adopted by a warm-hearted social worker, Margaret Lewin, and her husband, Charles. Years later, Khaila has gone through rehab and holds a steady job. After learning that her child is still alive, she challenges Margaret for the custody.

Glen, a complete stranger, appears at the door of Elizabeth Carter, a middle-aged woman, and claims to be the illegitimate son she gave away at birth.