Hilarious and outgoing, Brittany Forgler, is everybody’s best friend ― except her own. Her partying, underemployment and toxic relationships are catching up with her. She receives a startling wake-up call when a visit to the doctor reveals how unhealthy she is. Motivated to lose weight, but too broke for a gym and too proud to ask for help, Brit is at a loss, until her neighbor pushes her to run one sweaty block. Soon, she sets an almost unthinkable goal: the New York City Marathon.
A 30-year-old spends a wild weekend in Palm Springs and wakes up to find she has magically transformed into her 70-year-old self.
Melvin Udall, a cranky, bigoted, obsessive-compulsive writer of romantic fiction, is rude to everyone he meets, including his gay neighbor, Simon. After Simon is brutally attacked and hospitalized, Melvin finds his life turned upside down when he has to look after Simon's dog. In addition, Carol, the only waitress at the local diner who will tolerate him, leaves work to care for her chronically ill son, making it impossible for Melvin to eat breakfast.
In the midst of a new scheme to publicly report surgeons’ performance, a gifted surgeon’s life is thrown into disarray as her colleagues begin to close ranks, and even her partner, a nurse at the hospital, turns her back on her.
Martin is a neurotic web designer taking baby steps out of the isolation of his one-room apartment and his virtual reality. Mariana is an artist fresh out of a a long relationship. They are perfect for each other, live on the same street, in opposite buildings, but they never meet. Can the movement of a modern city of three million people bring them together?
Nelson is a man devoted to his advertising career in San Francisco. One day, while taking a driving test at the DMV, he meets Sara. She is very different from the other women in his life. Nelson causes her to miss out on taking the test and later that day she tracks him down. One thing leads to another and Nelson ends up living with her through a November that will change his life forever.
Hoping for a promotion, Elmer Fudd agrees to take care of his boss' dog and finds he must treat the pooch as a human.
Gemma agrees to look after her neighbours dog whilst they're away only to find it dead on the first day. Sparring between three versions of her own consciousness she must decide what to do.