Roberta is a bored suburban housewife who is fascinated with a woman, Susan, she only knows about by reading messages to and from her in the personals section of the newspaper. This fascination reaches a peak when an ad with the headline "Desperately Seeking Susan" proposes a rendezvous. Roberta goes too, and in a series of events involving amnesia and mistaken identity, steps into Susan's life.
In an effort to prevent family history from repeating itself, meddlesome mom Daphne Wilder attempts to set up her youngest daughter, Milly, with Mr. Right. Meanwhile, her other daughters try to keep their mom's good intentions under control.
In the late 1940s, a murderous couple known as the 'The Lonely Hearts Killers' kills close to a dozen people. Two detectives try to nab the duo who find their targets via the personals in the paper.
A tabloid editor assigns a young reporter to solve a murder the editor committed himself.
Magali, forty-something, is a winemaker and a widow: she loves her work but feels lonely. Her friends Rosine and Isabelle both want secretly to find a husband for Magali.
Susannah and Jesse Stanton divorced two years prior with three children. When Susannah starts dating a lawyer, the children decide to find someone for their father, sending a letter to a popular magazine called Alaskan Love. He receives a large number of responses, but the children later feel that his perfect match is Susannah, and they try to arrange a plan to bring them together.
Martha Beck, an obese nurse who is desperately lonely, joins a "correspondence club" and finds a romantic pen pal in Ray Fernandez. Martha falls hard for Ray, and is intent on sticking with him even when she discovers he's a con man who seduces lonely single women, kills them and then takes their money. She poses as Ray's sister and joins Ray on a wild killing spree, fueled by her lingering concern that Ray will leave her for one of his marks.
Driven by desire and desperate for self-love, Coral and Nicolás will abandon their past lives in a journey surrounded by murder.
Comedy about a woman who hosts a radio talk-show who turns thirty and worries about not having a husband. With the help of her gay brother, she places an personal advert in the local paper and meets a charming dentist. Unfortunately, she finds out he is married, and her brother also falls for him.
Soapy Gibson (Edward Ellis) and his wife Annie (Marjorie Rambeau) run a lonely hearts club in a small town. Even during the Depression years these were often "clip joints" - places where people with money but no mate got taken by someone offering the promise of companionship. However, Soapy and Annie are strictly on the level - and they have more than one reason to want to stay on the level. You see Soapy escaped from the law years ago, had some plastic surgery and changed his name, and has been living on the lam with his wife ever since.
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