Dr. Nathaniel Grant is a pioneering organ-transplant surgeon who takes risks that other doctors would not in order to save the lives of his patients. He works closely with his ex-wife, Kate Armstrong, an organ-donor coordinator with whom he has a volatile relationship. Grant's arrogance and willingness to perform risky procedures causes him to butt heads with the hospital administration. But his main focus is on his intense relationship with his job and his patients, often at the expense of his family.

Three Rivers is an American television medical drama that debuted on CBS on October 4, 2009, starring Alex O'Loughlin in the role of an infamous transplant surgeon in Pittsburgh, Pennsylvania. On November 30, 2009, after just eight episodes of the season had aired, CBS announced that Three Rivers had been pulled from their schedule with no plans to have it returned, and the series was later officially cancelled. However, the series later returned to the network on June 5, 2010 to burn off the remaining unaired episodes.