A case involving drug lords and murder in South Florida takes a personal turn for undercover detectives Sonny Crockett and Ricardo Tubbs. Unorthodox Crockett gets involved romantically with the Chinese-Cuban wife of a trafficker of arms and drugs, while Tubbs deals with an assault on those he loves.

Sherlock Holmes is forced to confront his age and health condition as he struggles to solve the murder of a fellow detective.