Jokes fly as the Tune Squad takes on the Nerdlucks in a hardcourt game to decide if the Looney Tunes remain here... or become attractions at a far-off galactic off-ramp called Moron Mountain. The Nerdlucks have a monstrous secret weapon: they've stolen the skills of top NBA stars like Charles Barkley and Patrick Ewing and become Monstars. But that's not all, folks. The Tune Squad’s secret weapon just happens to be the finest player in this or any other universe. He's outta this world. So's the fun.

When LeBron and his young son Dom are trapped in a digital space by a rogue A.I., LeBron must get them home safe by leading Bugs, Lola Bunny and the whole gang of notoriously undisciplined Looney Tunes to victory over the A.I.'s digitized champions on the court. It's Tunes versus Goons in the highest-stakes challenge of his life.