In the future when technological enhancements and robotics are a way of life, Major Motoko Kusanagi and Section 9 take care of the jobs that are too difficult for the police. Section 9 employs hackers, sharpshooters, detectives and cyborgs all in an effort to thwart cyber criminals and their plans to attack the innocent.

Inami and Tamaru work at the Public Security Mobile Investigation Unit Special Investigation Team, a team made up of specialists with different expertise. Inami tackles criminals with showy maneuvers, while Tamaru corners criminals with cool calculation. Together, the team tackles terrorists, new religious cults, military spies, secret narcotics organisations and complicit politicians.

An explosion take place in a street of Tokyo. Many people were killed or seriously injured. One casualty is Chihiro, the wife of Public Security chief inspector Kuraki Naotake.

While trying to find why his wife was being implicated in the explosion case, Kuraki comes into contact with Public Security sergeant Akeboshi Miki and Metropolitan Police Department inspector Osugi Ryota who are also investigating this case.