Palermo, Sicily, 1980. Mafia member Tommaso Buscetta decides to move to Brazil with his family fleeing the constant war between the different clans of the criminal organization. But when, after living several misfortunes, he is forced to return to Italy, he makes a bold decision that will change his life and the destiny of Cosa Nostra forever.

Italy, early '90s. Calm, clever and inscrutable, politician Giulio Andreotti has been synonymous with power for decades. He has survived everything: electoral battles, terrorist massacres, loss of friends, slanderous accusations; but now certain repentant mobsters implicate him in the crimes of Cosa Nostra.

Palermo, Sicily, 1984. Examining magistrate Giovanni Falcone allies with Tomasso Buscetta, a former mobster, to defeat the clan of Corleone, the ruthless Mafia faction that rules Cosa Nostra with an iron hand, cruelly eliminating all those who dare to oppose its immense power: other criminals, policemen, judges, even innocent civilians. One of them wants revenge, the other wants justice. But only one can survive such an unequal fight.

The story of how Sicilian Mafia boss Tommaso Buscetta (1928-2000), the Godfather of Two Worlds, revealed, starting in 1984, the deepest secrets of the organization, thus helping to convict the hundreds of mafiosi who were tried in the trial held in Palermo between 1986 and 1987.