In eighteenth-dynasty Egypt, Sinuhe, a poor orphan, becomes a brilliant physician and with his friend Horemheb is appointed to the service of the new Pharoah. Sinuhe's personal triumphs and tragedies are played against the larger canvas of the turbulent events of the 18th dynasty. As Sinuhe is drawn into court intrigues he learns the answers to the questions he has sought since his birth.

Hard-boiled archeologist Mark Brandon is searching for ancient tombs in Egypt when he is approached by beautiful Ann Mercedes, who convinces him to help her fulfill her deceased father's life's ambition - to provide solid proof of the biblical Joseph's travels in ancient Egypt. As an ex-pupil of Ann's father Mark accepts and the two embark on a search for the tomb of the Pharoah Ra Hotep, said to have had some connection with Joseph. The trail to the tomb is fraught with intrigue, betrayal, murder and the possibility that the tomb itself has been emptied of all its artifacts by ancient looters.