In a massive, mysterious chamber, fifty strangers awaken to find themselves trapped with no memory of how they got there. Organized in an inward-facing circle and unable to move, they quickly learn that every two minutes, one of them must die…executed by a strange device in the center of the room.

Kassie is a smart, fun-loving single woman who, despite her neurotic best friend Wally’s objections, decides it’s time to have a baby – even if it means doing it herself… with a little help from a charming sperm donor. But, unbeknownst to her, Kassie’s plans go awry because of a last-minute switch that isn’t discovered until seven years later… when Wally gets acquainted with Kassie’s cute, though slightly neurotic, son.

John is a brilliant linguistic scientist with a loving wife and daughter but with a massive gap in his life. Eight years ago, he turned up out of nowhere, with no memories except a recurring dream. He is sent tumbling down the proverbial rabbit hole after meeting a man that shares a similar condition and learning that there are more like him, all amnesiacs with extraordinary abilities. He convinces his brother-in-law, private investigator Carl, to help him uncover his true identity before his past can rise up to destroy him and his family.

Jane Ravenson finds herself in the middle of a grocery store with $10,000 in her coat pockets and no memory of her life or who she is. Her husband eventually finds her and she starts to believe that her family life is fine until she feels a deep, nightmarish paranoia that something is horribly and terribly wrong.