In Arizona in the late 1800s, infamous outlaw Ben Wade and his vicious gang of thieves and murderers have plagued the Southern Railroad. When Wade is captured, Civil War veteran Dan Evans, struggling to survive on his drought-plagued ranch, volunteers to deliver him alive to the "3:10 to Yuma", a train that will take the killer to trial.

Rocky, Colt and TumTum must battle an evil wealthy toxic waste dumper in order to save a local Indian tribe and their friend Joe. The 3 Ninjas must help find Joe's father and find a secret disk that contains evidence that could stop the toxic landfill that is destroying the Indian community. However the town is owned by the rich man and he controls the police and even the mayor. They must fight a motorcycle gang and renegade cowboys in this non-stop ninja adventure.