As Hercule Poirot enjoys a luxurious cruise down the Nile, a newlywed heiress is found murdered on board and every elegant passenger becomes a prime suspect.

A female cat wants to board a French cruise ship. Prior to the ship's departure, she crawls under a freshly-painted gate and gets a white streak atop her back and tail. Enter enamored Pepé Le Pew.

Sylvester Cat accepts a position as mouse-catcher on a ship, and his son, Junior, accompanies him. They encounter baby kangaroo Hippety Hopper being shipped from Australia and, as usual, mistake Hippety for a giant mouse.