Gode råd er dyre, da en milliontallig sværm af sydafrikanske dræberbier slår ned i det sydvestlige USA og parrer sig med de fredelige lokale arter. I kamp mod tiden og militærets generaler forsøger entomologen Bradford Crane at finde en måde at komme plagen til livs, inden den bevæger sig videre mod Houston.

A widow, Deputy Sheriff Jane Kozik, moves from Manhattan to Black Stone, New York, with her daughter Kelsey. There she expects to find a safe place to live. The day after moving, a homeless man is found dead in the tool shed of Jane's blind friend Beverly; an entomologist, Katherine is summoned to help with the investigation, along with Devin, Jane's brother-in-law and former boyfriend. Meanwhile, Kelsey befriends Eli, a scientist who has developed genetically modified wasps to the army as a weapon, and who is now trying to revert the process. When the wasps attack Black Stone, Jane, Devin and Eli team-up to attempt to destroy the swarm.

A strong-willed woman not only dominates her family of California winegrowers, but also has a strange hold on a colony of bees in her vineyard.

Corporate smuggling of South American killer bees into the United States results in huge swarms terrorizing the northern hemisphere. A small team of scientists work desperately to destroy the threat, but the bees soon mutate into a super-intelligent species that threatens the world.

Trouble strikes when an exhausted pop singer, sent on a vacation to a farm, realizes that the farm's owner grows deadly bees.

In this horror-drama the festive fun of the annual Mardi Gras celebration is brought to a halt when a swarm of African killer bees escape from a foreign freighter.

Giant killer bees attack scientists.

Killer bees escape from the secret laboratory where they were bred.