Steve Coogan plays Tommy Saxondale: an ex-roadie with anger management issues and a pest-control business. Tommy is a little arrogant, a little egotistical and feels the world owes him more respect than it typically shows him. He has an assistant named Raymond who lives in a spare room in Tommy's house, a live-in girlfriend named Magz who owns a T-shirt business, and a receptionist named Vicky who has a tendency to drive him up the wall.

Follow Billy Bretherton and his family of exterminators as they attempt to balance life at home with the drama of running one of the busiest pest removal companies in Louisiana. From colonies of ants to giant snakes, snapping alligators to roach infestations, pest removal is big business, and in the swamps of Louisiana, Billy the Exterminator has seen it all.