Den aldrende politimand Roger Murtaugh får til opgave at efterforske den prostituerede Amanda Hunsaker's død. Amanda er datter af en bankdirektør, som er en af Murtaugh's personlige venner fra deres tid sammen i Vietnam. Til at hjælpe ham med efterforskningen får Murtaugh en ny makker i skikkelse af den selvmordsplagede og småpsykotiske Martin Riggs. Det uortodokse makkerpars efterforskning fører dem på sporet af en gruppe tidligere lejesoldater, der smugler heroin ind i Los Angeles. Ikke alene bliver efterforskningen nu ekstremt farlig, den bliver også personlig, da lederne af gruppen vil have Riggs og Murtaugh slået ihjel!
Sheriffen i Kern County, Joe "Deke" Deacon, sendes til Los Angeles for at indsamle bevismateriale. I stedet bliver han indblandet i jagten på en seriemorder, der spreder skræk i byen. Efterforskningens leder, L.A.-sheriffen Jim Baxter, bliver imponeret over Deke's evner og engagerer ham under radaren. Men mens de leder efter morderen, ved Baxter ikke, at sagen åbner gamle sår i Deke's fortid, som afslører hemmeligheder, der truer mere end kun efterforskningen.
Politimanden Thomas Craven's verden styrter i grus, da hans voksne datter, Emma, bliver skudt lige uden for hans hoveddør. Alle går ud fra, at morderen var ude efter Craven, men snart får han mistanke om, at det faktisk var Emma, der var morderens mål. Med sit eget liv som indsats går Craven på jagt efter sandheden om Emma's død. Og snart støder han på en hemmelighed, der kan være nøglen til mordet.
Den småkorrupte politimand Rick får til opgave at passe på USA's forsvarsminister til et boksestævne. Da ministeren bliver skudt er der pludselig 14.000 mistænkte, og så er fanden løs i Laksegade.
Jack Cole er special agent. Han sættes ind på de vanskeligste kriminalsager. Han arbejder alene og er kendt for sine utraditionelle metoder. Så det er mere af nødvendighed end af lyst, at Politiet i L.A. tilkalder Cole fra New York i forbindelse med en række makabre mord. Cole får en lokal partner, Jim Campbell, som bestemt ikke er glad for sin nye makker. Senere opdager Cole, at et af ofrene er hans eks-kone, og at han samtidig er mistænkt som gerningsmanden - så er det tid til at tage andre metoder i brug...
Tom er politidetektiv, men degraderes til flodpatruljen, fordi han brokker sig. Han brokker sig, fordi politiet får dømt en stakkel for seriemord, mens Tom er sikker på, at morderen skal findes inden for politiets egne rækker. Og så begynder ligene af myrdede kvinder at hobe sig op langs Toms rute på floden. Alle ofrene er kvinder, Tom tidligere har kendt. Toms nye kvindelige partner tror ikke på hans konspirationsteori. Kan Tom tro på hende - eller er hun det næste offer?
Psykolog og politikommisær Dr. Alex Cross bliver voldsomt udfordret af en seriemorder, der leger katten efter musen med den erfarne efterforsker. Da seriemorder kommer for tæt på privatlivet, bliver Cross presset til det yderste af hans moralske og mentale grænser. Denne stramt komponerede action-thriller er baseret på James Pattersons populære roman "Cross", hvis hovedperson tidligere er blevet spillet af Morgan Freeman i filmene "Kiss the Girls" og "Along came a Spider".
Den charmerende filosofiprofessor Evan Birch forsøger at glemme de sidespring, der har været ved at koste ham hans ægteskab. Men da den populære cheerleader Joyce forsvinder, møder politimanden Malloy op hjemme hos Evan. Der er tilsyneladende beviser, som peger på Evan, og snart bliver han hovedmistænkt. Men er Evan virkelig den skyldige?
Walter Stackhouse er rig og succesfuld - og ulykkeligt gift med den smukke Clara. Da Clara findes død for foden af en klippe, begynder mistanken at falde på Walter. Det fører ham ind i en spiral af kaos, der tvinger ham til at lege katten-efter-musen med en snu morder og en overambitiøs politimand.
Vincent LaMarca is a dedicated and well-respected New York City police detective who has gone to great lengths to distance himself from his past, but then makes the terrible discovery that his own son has fallen into a life of crime.
A short Arizona motorcycle cop gets his wish and is promoted to Homicide following the mysterious murder of a hermit. He is forced to confront his illusions about himself and those around him in order to solve the case, eventually returning to solitude in the desert.
Warren Quimby manages a drugstore while trying to keep his volatile wife, Claire, happy. However, when Claire leaves him for a liquor store salesman, Warren can no longer bear it. He decides to assume a new identity in order to murder his wife's lover without leaving a trace. Along the way, his plans are complicated by an attractive neighbor, as well as a shocking discovery that opens up a new world of doubts and accusations.
Neglected by her workaholic husband, a young wife, Maren Abbott, meets a man through Wandering Eye - a networking website designed to facilitate extramarital liaisons. Charming as he is, she realizes she can't go through with the affair. When he is found brutally murdered in their hotel room, infidelity is the least of Maren's worries as she finds herself in the cross-hairs of a serial killer who uses the website to trawl for his next victims.
A veteran homicide detective who has witnessed his socialite girlfriend kill her husband sees his inexperienced brother assigned to the case.
A serial killer is loose on the streets of Atlantic City. His ten victims are prostitutes, his methods are ruthless and yet his motives are unknown. Two embattled homicide detectives, Mayfield and Jesse, are in a race against time to catch this killer. They have just a few hours to utilize all of their resources and prevent murder number eleven. But with very few leads, very little support, and luck playing against them they are in for a long night because being wrong is unforgiving and number eleven is already gone.
Just as her life is coming together, Allison experiences a terrible tragedy when her boyfriend is murdered by an intruder from whom the woman herself barely escapes. The police capture a man they believe to be the killer, but Allison, still unsettled, has her doubts. Things take a frightening turn when she meets her friend's new boyfriend and suspects him to be the killer.
Two friends land in hot water when they begin dating twins and one of the women ends up dead.
On New Year's eve in London, a provocative game spins out of control and ends in murder, the true killer elusive amidst conflicting testimony and hidden motives.
A serial killer is loose on the streets of LA, leaving behind a steaming trail of bodies marked with lipstick: the calling card of a Black Widow who loves them and leaves them dead. As homicide detectives unravel the case, they discover the victims all have one thing in common: they’re crooked ex-cops who escaped justice. But they didn’t escape the sting of the Black Widow. As the investigation hits ever closer to home, the police must consider that the killer could be one of their own, a vigilante who is taking the law into her own hands, and tracking these murders will take them through the dark and seedy underbelly of Los Angeles where they soon discover that revenge is a dish best served hot.
A white female detective is partnered with a black male detective to find the person who is committing a series of particularly vicious murders. During the course of the investigation the two begin to develop an attraction to each other, but the situation is complicated by the fact that he is married.