Anton is a cheerful but exceedingly non-ambitious 17-year-old stoner who lives to stay buzzed, watch TV, and moon over Molly, the beautiful girl who lives next door. However, it turns out that the old cliché about idle hands being the devil's playground has a kernel of truth after all.

Jon Lansdale is a comic book artist who loses his right hand in a car accident. The hand was not found at the scene of the accident, but it soon returns by itself to follow Jon around, and murder those who anger him.

A story of Naoufel, a young man who is in love with Gabrielle. In another part of town, a severed hand escapes from a dissection lab, determined to find its body again.

Five strangers board a train and are joined by a mysterious fortune teller who offers to read their Tarot cards. Five separate stories unfold: An architect returns to his ancestoral home to find a werewolf out for revenge; a doctor discovers his new wife is a vampire; a huge plant takes over a house; a musician gets involved with voodoo; an art critic is pursued by a disembodied hand.

Locals in an Italian village believe evil has taken over the estate of a recently deceased pianist where murder has taken place. The alleged killer: the pianist's severed hand.