A high school slacker who's rejected by every school he applies to opts to create his own institution of higher learning, the South Harmon Institute of Technology, on a rundown piece of property near his hometown.

Virginia Cunningham is confused upon finding herself in a mental hospital, with no memory of her arrival at the institution. Tormented by delusions and unable to even recognize her husband, Robert, she is treated by Dr. Mark Kik, who is determined to get to the root of her mental illness. As her treatment progresses, flashbacks depict events in Virginia's life that may have contributed to her instability.

Filmmaker Jonathan Caouette's documentary on growing up with his schizophrenic mother -- a mixture of snapshots, Super-8, answering machine messages, video diaries, early short films, and more -- culled from 19 years of his life.

For doctors “MARASMA” was a diagnosis: a state of deep organic deterioration, total loss of strength. In mental hospitals, people did not die of mental illness, but of marasmus. This is what the medical records say, which today reveal the most difficult stories: those of the last among the weakest, children and women. Through their testimonies we can also give voice to those who do not know, who do not want or can not remember.

A young woman travels through her psyche in order to find who murdered her lover, Juan.