During a stopover in Germany in the middle of a carefree road trip through Europe, two American girls find themselves alone at night when their car breaks down in the woods. Searching for help at a nearby villa, they are wooed into the clutches of a deranged retired surgeon who explains his mad scientific vision to his captives' utter horror. They are to be the subjects of his sick lifetime fantasy: to be the first to connect people, one to the next, and in doing so bring to life "the human centipede."

A dark secret connects middle-aged Katze and Brauth. The former has the clue that his end is near. The two meet again after years to share their last days in the old house of their past. With three women they met on their way, the atmosphere begins to recur a second time. When artist Heinrich decides to attend, the friends have their last chance to renew and cut with the history and to settle an old score. In the melancholy of the near end, Katze passes again all the situations in his life. In the hour of death, he is not alone anymore. His body is gone and his soul stays back in the same place where his destiny and fulfillment occurred.

Geoff, a man with an unusual compulsion to eat inedible objects, calls on the unorthodox services of backstreet practitioner Doctor Dora in order to cure his ailment.