Serien er baseret på figurer og elementer, der optræder i romanen Red Dragon af Thomas Harris og fokuserer på det spirende forhold mellem FBI special efterforsker Will Graham og Dr. Hannibal Lecter, en retsmedicinsk psykiater bestemt til at blive Graham mest snedige fjende

De er helt almindelige ejendomsmæglere gift med hinanden, indtil hun kommer ud for en dramatisk forandring, der sender dem mod død og ødelæggelse. På en god måde.

After causing a major incident, police officer Daigo Agawa takes his wife and daughter to live in the remote mountain village of Kuge. It seems the perfect place to recover from the ordeal, despite the mysterious disappearance of a previous officer posted there. One day, the body of an old woman is found on the mountain. The Goto family says she was attacked by a bear, but Daigo notices a human bite mark. It soon becomes clear that not all is as it seems in the village.

A journalist races to learn the truth when human remains are found in the home of self-proclaimed Satanist "Pazuzu".