داستان فیلم در مورد حمله‌ی ارواح به شهر منهتن می‌باشد که کل شهر را به تسخیر خود درآورده و به دنبال آن همه‌ی مردم را ناامید کرده‌اند. اما در این میان یک فیزیکدان با اختراع خود به کمک مردمش می‌‌آید تا با دستگاه خود ارواح را از شهر خارج کند. و…

The Spengler family returns to where it all started – the iconic New York City firehouse – to team up with the original Ghostbusters, who've developed a top-secret research lab to take busting ghosts to the next level. But when the discovery of an ancient artifact unleashes an evil force, Ghostbusters new and old must join forces to protect their home and save the world from a second Ice Age.

When a single mom and her two kids arrive in a small town, they begin to discover their connection to the original Ghostbusters and the secret legacy their grandfather left behind.

An animated movie set in the Ghostbusters world confirmed to be in the works. The movie is set to be from a ghost's perspective.