Lawyer Jessica Yau finds out about her husband's money laundering scheme and gets shot in the head. She survives, but loses her memory. She is cared for by Mei Mei Chen, a nurse she screwed over in a lawsuit before being shot.

The hilarious sequel to the 1989 hit The Yuppie Fantasia, Brief Encounter in Shinjuku brings back Lawrence Cheng as a thirty-something Hong Kong yuppie finding misadventures in love and marriage. Leung Foon and Ann reunite after the events of The Yuppie Fantasia, but issues still exist. Ann works overtime to be a better wife, and Leung Foon attempts mightily to be a model, upright husband.