When her mother suffers a heart attack, successful New York writer Stephanie Golden sets aside her job and fiancé to return to her hometown in Kansas. There she finds a family in turmoil and her younger sister Monica sinking into the dark world of drug addiction.

Set in the unique beauty of Oklahoma country, "Dome of Heaven" is the story of the Moses family, dysfunctionally struggling for decades, and which consists of a Cherokee father and German mother and their two adult children Franklin and Flutie. With challenges both personal and societal, each tries to find their place in a world and peace with each other, but so many complications of emotions, culture clash and misunderstanding often keeps them apart.