Cloud Atlas là một thiên sử thi về loài người mà trong đó, mỗi hành động của mỗi cá nhân lại có tác động, ảnh hưởng tới những con người khác tại quá khứ, hiện tại và tương lai. Sáu nhân vật chính cùng sáu câu truyện kéo dài hơn 5 thế kỉ bắt đầu tại ba lục địa, bắt đầu từ Nam Thái Bình Dương thế kỷ 19 kéo dài tới thời kì tận hậu thế tại Hawaii. Mỗi câu truyện được “dẫn dắt” bởi chính nhân vật của câu truyện kế tiếp. Sáu câu truyện nhỏ được kết hợp thành một cốt truyện thống nhất.

Nước Anh năm 1021. Rob Cole một chàng trai nghèo khổ, thề sẽ trở thành thầy thuốc và chiến thắng bệnh tật và cái chết. Anh phải trải qua con đường gian khó để tìm kiếm kiến thức bị bao vây bởi vô số thử thách và hy sinh, dẫn anh đến Isfahan xa xôi ở Ba Tư, nơi anh gặp Ibn Sina người chữa bệnh vĩ đại nhất trong thời đại của mình.

An accomplished headhunter risks everything to obtain a valuable painting owned by a former mercenary.

An African-American Mafia hit man who models himself after the samurai of ancient Japan finds himself targeted for death by the mob.

A young Austrian girl is kidnapped and held in captivity for eight years. Based on the real-life case of Natascha Kampusch.

A 9th century woman of English extraction born in the German city of Ingelheim disguises herself as a man and rises through the Vatican ranks.

Paris, Kingdom of France, August 18, 1572. To avoid the outbreak of a religious war, the Catholic princess Marguerite de Valois, sister of the feeble King Charles IX, marries the Huguenot King Henry III of Navarre.

Phim là câu chuyện về một cặp vợ chồng lớn tuổi, Georges và Anne, từng là giáo viên dạy nhạc. Cả hai sống hạnh phúc trong một ngôi nhà ấm cúng ở Paris, Pháp. Họ có một cô con gái cũng theo nghề cha mẹ nhưng sống ở nước ngoài. Đến một ngày, cơn đột quỵ khiến Anne bị liệt nửa người bên phải. Mọi hoạt động sinh hoạt thường ngày của bà giờ bị chi phối bởi Georges. Đã chung sống với nhau hàng chục năm, tình yêu của họ một lần nữa bị thử thách bởi trách nhiệm, bệnh tật, sự hy sinh và thời gian…

David, now an old man, is still king of Israel. Among his sons, the ambitious Adonijah and the clever Solomon, fierce rivals, since both are prospective heirs to the throne and only one can be.

Hector is a quirky psychiatrist who has become increasingly tired of his humdrum life. As he tells his girlfriend, Clara, he feels like a fraud: he hasn’t really tasted life, and yet he’s offering advice to patients who are just not getting any happier. So Hector decides to break out of his deluded and routine driven life. Armed with buckets of courage and child-like curiosity, he embarks on a global quest in hopes of uncovering the elusive secret formula for true happiness. And so begins a larger than life adventure with riotously funny results.

Made of four short tales, linked by a story filmed by Wim Wenders. Taking place in Ferrara, Portofino, Aix en Provence and Paris, each story, which always a woman as the crux of the story, invites to an inner travel, as Antonioni says "towards the true image of that absolute and mysterious reality that nobody will ever see".

When a hilariously dull policeman moves in with his best buddy in Munich, he has to deal with scandals, a corpse — and potential marriage.

1938. While the Nazi troops march into Vienna, the lawyer Josef Bartok hastily tries to escape to the USA with his wife but is arrested by the Gestapo. Bartok remains steadfast and refuses to cooperate with the Gestapo that requires confidential information from him. Thrown into solitary confinement, Bartok is psychologically tormented for months and begins to weaken. However, when he steals an old book about chess it sets him on course to overcome the mental suffering inflicted upon him, until it becomes a dangerous obsession.

A policeman suspects that several bizarre deaths in the same family were murders and that the killer is a mysterious woman who just moved to the village.

Tom Sawyer has a head full of pranks and drives when he invents is not just a new adventure, preferably around with his best buddy Huck Finn - much to the chagrin of his Aunt Polly with Tom and his half-brother Sid in the town of St. Petersburg on the Mississippi river.

Germany in the early 19th century. "Die Vermessung der Welt" follows the two brilliant and eccentric scientists Alexander von Humboldt and Carl Friedrich Gauss on their life paths.

Hanna and Simon are in a 20 year marriage with an unexciting relationship. By chance, they both meet and start separate affairs with Adam. Adam has no idea that his two lovers are married, until they are all found out when Hanna becomes pregnant, with the natural doubts stemming from their situation.

A love triangle forms between post-Enlightenment writer Friedrich Schiller and two sisters -- one who became his wife, and the other, his biographer.

14-year old Erik gets sent to live with his older brother, Henry, during the summer as his mother is dying in cancer. Henry starts dating Ewa, who is married to Berra. A few days after Ewa shows up battered and bruised from an altercation with Berra, he is found dead on a nearby parking lot.

Vienna, 1937, on the eve of the annexation of Austria into Nazi Germany. The young and inexperienced Franz Huchel begins to learn about both the joys and hardships of life by working as an apprentice to the mutilated war veteran Otto Trsnjek in a small tobacco shop, where he meets the famous psychiatrist Sigmund Freud, a regular customer, who will become a valuable friend in times of chaos and uncertainty.