Inspired by the fictional Dr. Heiter, disturbed loner Martin dreams of creating a 12-person centipede and sets out to realize his sick fantasy.

During a stopover in Germany in the middle of a carefree road trip through Europe, two American girls find themselves alone at night when their car breaks down in the woods. Searching for help at a nearby villa, they are wooed into the clutches of a deranged retired surgeon, who has a very disturbed vision.

Taking inspiration from The Human Centipede films, the warden of a notorious and troubled prison looks to create a 500-person human centipede as a solution to his problems.