It's the end of yet another night at Hastings Supermarket, a grocery store in Buck Lake, Arizona. But just before closing, a group of masked and armed to the teeth militants invades the store and take everyone hostage

In Texas, the aspirant actress Nicole Carrow runs away home to Los Angeles with her boyfriend Jess Hilts. They drive through a shortcut in an old road, and when they park in a rest stop, Jess is abducted by the sadistic driver of an old yellow truck. Along the night, Nicole is threatened by the sick maniac, while mysterious things happen to her in the place.

Admitted to Mt. Abaddon Hospital for a routine procedure, George Grieves discovers that his condition is much more serious and complicated than originally expected; and as his own fears begin to manifest around him, he learns that Mt. Abaddon is not a place where people come to get better... it is a place where people come to die.

After being captured and tortured by the psychopath Otis, teen cheerleader Riley Lawson escapes and informs her parents, who quickly sidestep sluggish FBI agents and take matters into their own hands. But the Lawsons' revenge plan hits a snag when Otis's unusual brother enters the picture.

One year after running away from home, Nicole and Jesse are still missing. When Jesse's brother, Tom, returns home from active duty, he sets out with his friends Marilyn and Jared to locate the lost couple. Their search leads them to the stretch of old highway with a mysterious Rest Stop, where they find themselves in the same predicament as Nicole and Jesse: confronting a madman.

Two paramedics responding to an emergency call find themselves kidnapped by a religious sect whose great obsession is to stop the end of the world by committing suicide and killing people.