Retired C.I.A. agent Frank Moses reunites his unlikely team of elite operatives for a global quest to track down a missing portable nuclear device.

Framed for crimes against the country, the G.I. Joe team is terminated by Presidential order. This forces the G.I. Joes into not only fighting their mortal enemy Cobra; they are forced to contend with threats from within the government that jeopardize their very existence.

Former race car driver Brent Magna is pitted against the clock. Desperately trying to save the life of his kidnapped wife, Brent commandeers a custom Ford Shelby GT500 Super Snake, taking it and its unwitting owner on a high-speed race against time, at the command of the mysterious villain holding his wife hostage.