Twentysomething Brooklynites Mara and Jo have been close friends since middle school. Gradually, it becomes apparent that the increasingly unstable Jo has troubles that may be the result of substance abuse, or an even deeper problem. Over the course of a decade, the more stable Mara tries to help.

17-year-old Jackie is in distress as her older brother Matthew gets his first girlfriend and prepares for college. Though Matthew does not share her incestuous desire, Jackie fights the intrusion of reality on her idyllic childhood world.

Caterina was born in South America but lives in New York. Her willingness to make close emotional connections to others is as much of a burden as it is a gift.

Mimi and Michael are close friends after a brief and unsuccessful dating interlude years before. Michael has remained in love with Mimi over the years, but Mimi, who has just broken up with her long-time boyfriend, seems willing to try romance with Michael a second time. The spark between them is kindled again, however, during a weekend picnic outing, Mimi, suddenly enthusiastic, proposes to Michael abruptly. The two marry and head off on a honeymoon to Pennsylvania without ever having slept with each other.