Children's author Dorothy Gale makes a decent living continuing her grandfather's series of Oz books. When a new agent enters the scene, Dorothy moves to New York city. In the midst of a major business deal for her books, Dorothy discovers that her books are not based on her imagination, but on repressed memories. While Dorothy struggles with the revelation, she is forced to confront The Wicked Witch of the West, who has descended upon the Big Apple, determined to settle an old score.

Daffy undead gal Penny Dreadful, her smitten zombie buddy Ned, and lycanthrope Wolfboy relate three tales of terror in an old rundown movie theater: A young couple find themselves being stalked by a lethal jack-in-the-box in "Slash-in-the-Box;" mousy young lady Alice tries to figure out what exactly happened to her last night in "The Morning After;" and a group of friends encounter an eccentric backwoods family after their van breaks down in the middle of nowhere in "The Slaughter House."

Unknown to most of their prey, the Lost Girls are far from human. When their leader Gracie begins dying, that balance is thrown into jeopardy and the Lost Girls must stop an erupting vampire revolution, race to find a cure and conquer their own personal demons before it is too late.