Daisy Jones, un’adolescente disaffezionata, si fa spazio nella scena rock della Sunset Strip. Nella periferia della Pennsylvania, Billy Dunne, il fratello Graham e gli amici Eddie e Warren formano una band per fuggire da quel contesto. Quando Billy e Daisy si incontrano, il talento di lei e l'ambizione di lui contribuiscono a cambiare le loro vite nel bene e nel male. Questo è ciò che è successo.

Dopo aver trovato la sua voce, Daisy naviga nella scena musicale di LA, grazie all’amica Simone e al leggendario produttore Teddy Price. A LA, con a bordo la tastierista Karen Sirko, i Dunne Brothers affrontano delle sfide per emergere. Dopo un incontro fortuito con Teddy e un'oppurtunità, la band è affranta nello scoprire che i demoni di Billy minacciano di sopraffare il suo potenziale.

Un Billy appena uscito dalla dipendenza dall'alcol cerca di conciliare la musica con le responsabilità familiari, mentre il resto della band raccoglie i pezzi dopo un tour disastroso. Daisy trova più difficile comporre musica quando ci sono aspettative. Billy scrive una nuova canzone e Teddy si rende conto che una collaborazione tra i due cantautori potrebbe essere la risposta ai loro problemi.

The Six get a taste of the life they’ve been working towards when their collaboration with Daisy becomes a hit. Rather than defuse the friction between co-songwriters, this only exacerbates it — until Camila negotiates peace. Meanwhile, Graham wrestles with whether to profess his feelings for Karen at a house party in the Canyon, knowing that a wrong move could threaten the survival of the band.

Fresh off their newly-acquired fame and success, Daisy Jones & The Six gear up to record their first album together. However, when Billy and Daisy prove unwilling to collaborate on each other’s material, they have no choice but to try and write something from the ground up together. This proves more challenging than either expected. Meanwhile, Karen sees a new side of Graham during a beach trip.

The band records their seminal album “Aurora,” the heart of which is the always complicated but typically fruitful collaboration between Billy and Daisy. As their working relationship intensifies, their personal relationship threatens to completely implode, causing Daisy to make an impulsive decision. Meanwhile, Camila harbors a secret of her own.

As her relationship with Bernie deepens, Simone struggles to come to terms with her identity while finding her voice in the nascent disco scene of New York City. A telegram from Daisy suggests she’s in trouble and Simone drops everything to rescue her. What she finds isn’t exactly what she expected.

As the Aurora tour begins, the band — now reunited with Daisy Jones — must come to terms with their meteoric rise to superstardom. With tension between Billy and Daisy at an all-time high, Billy’s frustration simmers to a boil while Daisy’s self-destructive habits turn tragic. Meanwhile Karen and Graham’s secret is revealed.

Her spirit broken, Daisy struggles to perform during their appearance on SNL, finding comfort in the last person she expects. After a triumphant return to their hometown Pittsburgh, the band is given a heroes’ welcome. But antipathy among the members clouds their performance and threatens their future. Meanwhile, Graham and Karen’s romance is threatened when Karen must make a difficult decision.

In what will become their final performance, Daisy Jones & The Six perform to a sold-out crowd at Soldier Field in Chicago, Illinois. This is the story of that fateful day — and how their lives were forever changed as a result.